Study Background: Ketamine Treatment at the VA San Diego Medical Center

Predicting Ketamine Treatment Outcomes: Key Findings and Implications

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Understanding which patients are most likely to respond to ketamine therapy is one of the most important task in the treatment of depression. Introduction The study "Predicting non-response to ketamine for depression: An exploratory…
The Comparative Effectiveness of Ketamine vs. Traditional Antidepressants: Personal Stories

The Comparative Effectiveness of Ketamine vs. Traditional Antidepressants: Personal Stories

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Introduction: What the Clinical Research Shows Recent clinical studies have explored the comparative effectiveness of ketamine and traditional antidepressants in treating depression. The quantitative differences are striking: Remission…
Unlocking the Brain: How the Lateral Habenula Influences Depression and Ketamine Therapy

Unlocking the Brain: How the Lateral Habenula Influences Depression and Ketamine Therapy

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The lateral habenula (LHb) stands out as a critical structure in understanding depression. This blog explores the LHb's role in the intricate landscape of neuroscience, its connection to depressive symptoms, and how ketamine therapy offers…
Ketamine and the Future of Mental Health: Insights from the 2024 Oxford International Conference

Ketamine and the Future of Mental Health: Insights from the 2024 Oxford International Conference

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Introduction The Oxford Ketamine International Conference in March 2024 brought together leading experts and researchers from around the world to explore the basic science and therapeutic use of ketamine.  Oxford, with its esteemed university…
How Stress and Bipolar Disorder Interact: Causes, Course, and Treatment

How Stress and Bipolar Disorder Interact: Causes, Course, and Treatment

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Stress and bipolar disorder (BD) interact bidirectionally. Stress, particularly in early life, appears to have lasting effects and marks for early onset of BD, although the exact mechanism is poorly understood. The relationship of stress…
Understanding Methylfolate: Genetic Connection and Clinical Insights

Understanding Methylfolate: Genetic Connection and Clinical Insights

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In the ever-evolving landscape of mental health treatments, let's shine the spotlight on methylfolate, a form of folate (or folic acid, also known as vitamin B9), in the fight against depression.  Folate, a vital nutrient for neurotransmitter…
Don't Throw Out the Serotonin Theory Just Yet!

Don’t Throw Out the Serotonin Theory Just Yet!

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The serotonin theory of depression has been around for a good 60 years and is often used as justification for the use of antidepressants, specifically selective serotonin re-uptake inhibitors (SSRIs). Understandably, a review published…
A New PAM on the Block

A New PAM on the Block

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Most of our readers know about antianxiety medications like Valium or Klonopin, and may know that their generic names are diazepam or clonazepam. The “pam” in these names stands for Positive Allosteric Modulator, and this fancy term means…
The "Pipeline"

The “Pipeline”

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There are several exciting developments in the field of antidepressants, with various drugs currently in the pipeline. These new treatments aim to provide better efficacy and fewer side effects compared to existing antidepressants. Here are…
Cough Medicine for Depression?

Cough Medicine for Depression?

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Yes, cough medicine! This blog entry touches upon the same issue that was detailed in the “What’s In a Name...” blog entry of November 2020. Medications are "born” with a certain designation, which then follows them throughout…